2,100 research outputs found
Linguistic incompetence: giving an account of researching multilingually
This paper considers the place of linguistic competence and incompetence in the context of researching multilingually. It offers a critique of the concept of competence and explores the performative dimensions of multilingual research and its narration, through the philosophy of Judith Butler, and in particular her study Giving an account of oneself. It explores aspects of risk, justice, narrative limit and a morality of multilingualism in emergent multilingual research frameworks. These theoretical dimensions are explored through consideration of âlinguistically incompetentâ ethnographic work with refugees and asylum seekers, in contexts of hospitality and in life long learning research in the Gaza Strip, and of early attempts to learn new languages. The paper offers a prospect of a relational approach to researching multilingually and affirms the vulnerability at the heart of linguistic hospitality
Loudly sing cuckoo : More-than-human seasonalities in Britain
This research was funded by a grant from the Arts and Humanities Research Council, grant number AH/E009573/1.Peer reviewedPostprin
More than a method? Organisational ethnography as a way of imagining the social
© 2016 Informa UK Limited, trading as Taylor & Francis Group. The authorsâtwo anthropologists and an organisational theorist, all organisational ethnographersâdiscuss their understanding and practices of organisational ethnography (OE) as a way of imagining and reflect on how similar this understanding may be for young organisational researchers and students in particular. The discussion leads to the conclusion that OE may be regarded as a methodology but that it has a much greater potential when it is reclaiming its roots: to become a mode of doing social science on the meso-level. The discussion is based on an analysis of both historical material and the contemporary learning experiences of teaching OE as more than a method to our students
Understanding Anthropological Understanding: for a merological anthropology
In this paper I argue for a merological anthropology in which ideas of âpartialityâ and âpractical adequacyâ provide a way out of the impasse of relativism which is implied by post-modernism and the related abandonment of a concern with âtruthâ. Ideas such as âaptnessâ and âfaithfulnessâ enable us to re-establish empirical foundations without having to espouse a simple realism which has been rightly criticised. Ideas taken from ethnomethodology, particularly the way we bootstrap from âpractical adequacyâ to âwarrants for confidenceâ point to a merological anthropology in which we recognize that we do not and cannot know everything, but that we can have reasons for being confident in the little we know
Beings in their own right? Exploring Children and young people's sibling and twin relationships in the Minority World
This paper examines the contributions that the sociological study of sibship and twinship in the Minority World can make to childhood studies. It argues that, in providing one forum within which to explore children and young people's social relationships, we can add to our understanding of children and young people's interdependence and develop a more nuanced understanding of agency. As emergent subjects, children, young people and adults are in a process of âbecomingâ. However, this does not mean that they can âbecomeâ anything they choose to. The notion of negotiated interdependence (Punch 2002) is useful in helping us to grasp the contingent nature of children and young people's agency
My mother or father: person, metaperson, and transcendence in ethnographic theory
How do humans, who are materially composed biological constructs, come to transcend, that is, to see themselves as present in the world? This paper sustains that, in order to understand transcendence in personhood, we have to see the latter as a product of dividual not individual participation, as initially proposed by LĂ©vy-Bruhl and recently developed by a number of phenomenologically inspired cognitive scientists. Personal ontogeny is what explains the relation between essence and existence in the case of metapersons (ghosts, deities, ancestors, some animals, etc.). In order to explore this problem, I discuss a minor occurrence that took place in my presence without my noticing it at the time when I was visiting an Afro-Brazilian temple compound in coastal Bahia (NE Brazil) in July 2011
The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer
© Evans et al. Nrf2 is a transcription factor that regulates cellular stress response and irinotecan-metabolising pathways. Its aberrant activity has been reported in a number of cancers, although relatively few studies have explored a role for Nrf2 in colorectal cancer (CRC). This study assessed the expression of Nrf2 in patient CRC tissues and explored the effect of Nrf2 modulation alone, or in combination with irinotecan, in human (HCT116) and murine (CT26) cell lines in vitro and in an orthotopic syngeneic mouse model utilising bioluminescent imaging. Using a tissue microarray, Nrf2 was found to be overexpressed (p < 0.01) in primary CRC and metastatic tissue relative to normal colon, with a positive correlation between Nrf2 expression in matched primary and metastatic samples. In vitro experiments in CRC cell lines revealed that Nrf2 siRNA and brusatol, which is known to inhibit Nrf2, decreased viability and sensitised cells to irinotecan toxicity. Furthermore, brusatol effectively abrogated CRC tumour growth in subcutaneously and orthotopicallyallografted mice, resulting in an average 8-fold reduction in luminescence at the study end-point (p=0.02). Our results highlight Nrf2 as a promising drug target in the treatment of CRC
Self-Similar Interpolation in Quantum Mechanics
An approach is developed for constructing simple analytical formulae
accurately approximating solutions to eigenvalue problems of quantum mechanics.
This approach is based on self-similar approximation theory. In order to derive
interpolation formulae valid in the whole range of parameters of considered
physical quantities, the self-similar renormalization procedure is complimented
here by boundary conditions which define control functions guaranteeing correct
asymptotic behaviour in the vicinity of boundary points. To emphasize the
generality of the approach, it is illustrated by different problems that are
typical for quantum mechanics, such as anharmonic oscillators, double-well
potentials, and quasiresonance models with quasistationary states. In addition,
the nonlinear Schr\"odinger equation is considered, for which both eigenvalues
and wave functions are constructed.Comment: 1 file, 30 pages, RevTex, no figure
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